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Interactions médicamenteuses

Cefotetan + Streptomycin

Gravité: Modérée

Cefotetan and Streptomycin: moderate interaction.

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Résumé

Streptomycin is nephrotoxic and ototoxic, and cephalosporins have been reported to add to aminoglycoside kidney injury in some patients. Renal impairment would then raise streptomycin levels and the risk of ototoxicity.

Ce que signifie cette interaction, en termes simples

Cefotetan and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Cefotetan belongs to Anti Bacterial; Streptomycin belongs to Anti Bacterial.

Niveau de preuve: Low

Pourquoi elle survient

Possible additive nephrotoxicity, with reduced renal clearance of streptomycin if kidney function declines.

Conduite à tenir

Monitor serum creatinine and streptomycin levels, and adjust the streptomycin dose to renal function. Watch for hearing loss or vestibular symptoms.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cefotetan with Streptomycin?

MediHelp rates the interaction as moderate. Cefotetan and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Streptomycin is nephrotoxic and ototoxic, and cephalosporins have been reported to add to aminoglycoside kidney injury in some patients. Renal impairment would then raise streptomycin levels and the risk of ototoxicity.

How serious is the interaction between Cefotetan and Streptomycin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and streptomycin levels, and adjust the streptomycin dose to renal function. Watch for hearing loss or vestibular symptoms.

What other medicines interact with Streptomycin?

MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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