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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Cenobamate + Lorlatinib

Gravité: Majeure

Cenobamate and Lorlatinib: major interaction.

Dernière mise à jour

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Résumé

Cenobamate induces CYP3A4 and may substantially lower lorlatinib exposure. Strong inducers of this kind can cause loss of lorlatinib efficacy, and lorlatinib itself can raise liver enzymes when exposure is altered or combined with inducers.

Ce que signifie cette interaction, en termes simples

Cenobamate and Lorlatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cenobamate belongs to Central Nervous System; Lorlatinib belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Cenobamate induces CYP3A4, accelerating lorlatinib clearance.

Conduite à tenir

Avoid the combination if an alternative antiseizure drug is possible; otherwise monitor tumor response and liver enzymes closely.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cenobamate with Lorlatinib?

MediHelp rates the interaction as major. Cenobamate and Lorlatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cenobamate induces CYP3A4 and may substantially lower lorlatinib exposure. Strong inducers of this kind can cause loss of lorlatinib efficacy, and lorlatinib itself can raise liver enzymes when exposure is altered or combined with inducers.

How serious is the interaction between Cenobamate and Lorlatinib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative antiseizure drug is possible; otherwise monitor tumor response and liver enzymes closely.

What other medicines interact with Lorlatinib?

MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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