Interactions médicamenteuses
Cephaloridine + Furosemide
Gravité: Majeure
Cephaloridine and Furosemide: major interaction.
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Résumé
Cephaloridine is a markedly nephrotoxic cephalosporin that is no longer in general use, and loop diuretics were reported to increase its renal toxicity. The combination could cause acute tubular injury, particularly with volume depletion.
Ce que signifie cette interaction, en termes simples
Cephaloridine and Furosemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Additive proximal tubular toxicity, with diuretic-induced volume depletion increasing renal cephaloridine accumulation.
Conduite à tenir
Avoid the combination and choose a less nephrotoxic antibiotic. If it cannot be avoided, monitor renal function closely and maintain hydration.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Furosemide
- Amifostine + Furosemide Majeure
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- Carbenoxolone + Furosemide Majeure
- Cisplatin + Furosemide Majeure
- Digoxin + Furosemide Majeure
- Ethacrynic acid + Furosemide Majeure
Questions fréquentes
Can I take Cephaloridine with Furosemide?
MediHelp rates the interaction as major. Cephaloridine and Furosemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cephaloridine is a markedly nephrotoxic cephalosporin that is no longer in general use, and loop diuretics were reported to increase its renal toxicity. The combination could cause acute tubular injury, particularly with volume depletion.
How serious is the interaction between Cephaloridine and Furosemide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a less nephrotoxic antibiotic. If it cannot be avoided, monitor renal function closely and maintain hydration.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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