Drug interactions
Cephaloridine + Furosemide
Severity: Major
Cephaloridine and Furosemide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephaloridine is a markedly nephrotoxic cephalosporin that is no longer in general use, and loop diuretics were reported to increase its renal toxicity. The combination could cause acute tubular injury, particularly with volume depletion.
What this interaction means in plain words
Cephaloridine and Furosemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive proximal tubular toxicity, with diuretic-induced volume depletion increasing renal cephaloridine accumulation.
What to do
Avoid the combination and choose a less nephrotoxic antibiotic. If it cannot be avoided, monitor renal function closely and maintain hydration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
- Ethacrynic acid + Furosemide Major
Frequently asked questions
Can I take Cephaloridine with Furosemide?
MediHelp rates the interaction as major. Cephaloridine and Furosemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cephaloridine is a markedly nephrotoxic cephalosporin that is no longer in general use, and loop diuretics were reported to increase its renal toxicity. The combination could cause acute tubular injury, particularly with volume depletion.
How serious is the interaction between Cephaloridine and Furosemide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a less nephrotoxic antibiotic. If it cannot be avoided, monitor renal function closely and maintain hydration.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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