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Interactions médicamenteuses

Ceritinib + Eletriptan

Gravité: Contre-indiquée

Ceritinib and Eletriptan: contraindicated interaction.

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Résumé

Ceritinib is a strong CYP3A4 inhibitor and may considerably raise eletriptan exposure. Elevated eletriptan levels increase the likelihood of vasospastic and hypertensive adverse effects.

Ce que signifie cette interaction, en termes simples

Ceritinib and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Ceritinib belongs to Oncology; Eletriptan belongs to Central Nervous System.

Niveau de preuve: Low

Pourquoi elle survient

Ceritinib inhibits CYP3A4, reducing first-pass and systemic clearance of eletriptan.

Conduite à tenir

Avoid eletriptan during ceritinib therapy and for 72 hours after a strong CYP3A4 inhibitor. Use a triptan not metabolized mainly by CYP3A4.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Ceritinib with Eletriptan?

MediHelp rates the interaction as contraindicated. Ceritinib and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ceritinib is a strong CYP3A4 inhibitor and may considerably raise eletriptan exposure. Elevated eletriptan levels increase the likelihood of vasospastic and hypertensive adverse effects.

How serious is the interaction between Ceritinib and Eletriptan?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid eletriptan during ceritinib therapy and for 72 hours after a strong CYP3A4 inhibitor. Use a triptan not metabolized mainly by CYP3A4.

What other medicines interact with Eletriptan?

MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Eletriptan page.

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