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Interactions médicamenteuses

Chloroquine + Dapsone

Gravité: Modérée

Chloroquine and Dapsone: moderate interaction.

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Résumé

Both drugs can cause hemolysis and methemoglobinemia, especially in patients with G6PD deficiency. Combined use may add to this hematologic toxicity.

Ce que signifie cette interaction, en termes simples

Chloroquine and Dapsone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Chloroquine belongs to Anti Parasitic; Dapsone belongs to Anti Bacterial.

Niveau de preuve: Low

Pourquoi elle survient

Additive oxidative hematologic toxicity; the precise interaction mechanism is not fully established.

Conduite à tenir

Check G6PD status before use and monitor hemoglobin and methemoglobin levels during combined therapy.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Chloroquine with Dapsone?

MediHelp rates the interaction as moderate. Chloroquine and Dapsone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause hemolysis and methemoglobinemia, especially in patients with G6PD deficiency. Combined use may add to this hematologic toxicity.

How serious is the interaction between Chloroquine and Dapsone?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check G6PD status before use and monitor hemoglobin and methemoglobin levels during combined therapy.

What other medicines interact with Chloroquine?

MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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