Drug interactions
Chloroquine + Dapsone
Severity: Moderate
Chloroquine and Dapsone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause hemolysis and methemoglobinemia, especially in patients with G6PD deficiency. Combined use may add to this hematologic toxicity.
What this interaction means in plain words
Chloroquine and Dapsone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Dapsone belongs to Anti Bacterial.
Why it happens
Additive oxidative hematologic toxicity; the precise interaction mechanism is not fully established.
What to do
Check G6PD status before use and monitor hemoglobin and methemoglobin levels during combined therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Frequently asked questions
Can I take Chloroquine with Dapsone?
MediHelp rates the interaction as moderate. Chloroquine and Dapsone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause hemolysis and methemoglobinemia, especially in patients with G6PD deficiency. Combined use may add to this hematologic toxicity.
How serious is the interaction between Chloroquine and Dapsone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check G6PD status before use and monitor hemoglobin and methemoglobin levels during combined therapy.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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