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Interactions médicamenteuses

Chloroquine + Cisapride

Gravité: Contre-indiquée

Chloroquine and Cisapride: contraindicated interaction.

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Résumé

Both drugs can prolong the QT interval. Used together they raise the risk of torsades de pointes and sudden cardiac death. Cisapride is already restricted because of this risk.

Ce que signifie cette interaction, en termes simples

Chloroquine and Cisapride are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Chloroquine belongs to Anti Parasitic; Cisapride belongs to Gastrointestinal Tract.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive blockade of cardiac hERG potassium channels causing delayed repolarization and QT prolongation.

Conduite à tenir

Avoid the combination; use a non-QT-prolonging prokinetic or antimalarial alternative. If unavoidable, obtain a baseline ECG and correct potassium and magnesium before and during therapy.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Chloroquine with Cisapride?

MediHelp rates the interaction as contraindicated. Chloroquine and Cisapride are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can prolong the QT interval. Used together they raise the risk of torsades de pointes and sudden cardiac death. Cisapride is already restricted because of this risk.

How serious is the interaction between Chloroquine and Cisapride?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a non-QT-prolonging prokinetic or antimalarial alternative. If unavoidable, obtain a baseline ECG and correct potassium and magnesium before and during therapy.

What other medicines interact with Cisapride?

MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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