Interactions médicamenteuses
Cholestyramine + Deferasirox
Gravité: Majeure
Cholestyramine and Deferasirox: major interaction.
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Résumé
Cholestyramine lowers deferasirox exposure, which may reduce iron chelation efficacy and allow iron overload to progress.
Ce que signifie cette interaction, en termes simples
Cholestyramine and Deferasirox can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cholestyramine belongs to Cardiovascular; Deferasirox belongs to Miscellaneous.
Pourquoi elle survient
Cholestyramine likely binds deferasirox and interrupts its enterohepatic recirculation, lowering systemic exposure.
Conduite à tenir
Avoid the combination where possible. If it is required, monitor serum ferritin and clinical response and adjust the deferasirox dose accordingly.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Cholestyramine
- Cholestyramine + Cholic acid Majeure
- Cholestyramine + Leflunomide Majeure
- Cholestyramine + Levothyroxine Majeure
- Cholestyramine + Mycophenolate Majeure
- Cholestyramine + Mycophenolate mofetil Majeure
- Cholestyramine + Mycophenolic acid Majeure
Autres interactions de Deferasirox
- Acetylsalicylic acid + Deferasirox Majeure
- Alosetron + Deferasirox Majeure
- Aluminum hydroxide + Deferasirox Majeure
- Amikacin + Deferasirox Majeure
- Argatroban + Deferasirox Majeure
- Aspirin / citric acid / sodium bicarbonate + Deferasirox Majeure
Questions fréquentes
Can I take Cholestyramine with Deferasirox?
MediHelp rates the interaction as major. Cholestyramine and Deferasirox can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cholestyramine lowers deferasirox exposure, which may reduce iron chelation efficacy and allow iron overload to progress.
How serious is the interaction between Cholestyramine and Deferasirox?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it is required, monitor serum ferritin and clinical response and adjust the deferasirox dose accordingly.
What other medicines interact with Cholestyramine?
MediHelp also lists interactions of Cholestyramine with, for example, Cholic acid, Leflunomide, Levothyroxine. The full list is on the Cholestyramine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
