Interactions médicamenteuses
Cholestyramine + Mycophenolic acid
Gravité: Majeure
Cholestyramine and Mycophenolic acid: major interaction.
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Résumé
Cholestyramine binds mycophenolic acid and interrupts its enterohepatic recirculation, substantially lowering exposure. This may cause loss of immunosuppressive effect and graft rejection.
Ce que signifie cette interaction, en termes simples
Cholestyramine and Mycophenolic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cholestyramine belongs to Cardiovascular; Mycophenolic acid belongs to Miscellaneous.
Pourquoi elle survient
Bile acid sequestrant binds mycophenolate glucuronide and MPA in the gut, preventing reabsorption.
Conduite à tenir
Avoid coadministration; use an alternative lipid-lowering agent. If unavoidable, monitor for rejection and consider MPA exposure monitoring.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Mycophenolic acid
Autres interactions de Cholestyramine
- Cholestyramine + Cholic acid Majeure
- Cholestyramine + Deferasirox Majeure
- Cholestyramine + Leflunomide Majeure
- Cholestyramine + Levothyroxine Majeure
- Cholestyramine + Mycophenolate Majeure
- Cholestyramine + Mycophenolate mofetil Majeure
Questions fréquentes
Can I take Cholestyramine with Mycophenolic acid?
MediHelp rates the interaction as major. Cholestyramine and Mycophenolic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cholestyramine binds mycophenolic acid and interrupts its enterohepatic recirculation, substantially lowering exposure. This may cause loss of immunosuppressive effect and graft rejection.
How serious is the interaction between Cholestyramine and Mycophenolic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration; use an alternative lipid-lowering agent. If unavoidable, monitor for rejection and consider MPA exposure monitoring.
What other medicines interact with Mycophenolic acid?
MediHelp also lists interactions of Mycophenolic acid with, for example, Activated charcoal, Azathioprine, Ganciclovir. The full list is on the Mycophenolic acid page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
