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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Cholestyramine + Leflunomide

Gravité: Majeure

Cholestyramine and Leflunomide: major interaction.

Dernière mise à jour

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Résumé

Cholestyramine binds teriflunomide in the gut and interrupts its enterohepatic recirculation, causing a marked fall in plasma levels. This is exploited for rapid elimination after leflunomide toxicity, but unintended use reduces efficacy.

Ce que signifie cette interaction, en termes simples

Cholestyramine and Leflunomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cholestyramine belongs to Cardiovascular; Leflunomide belongs to Musculoskeletal.

Niveau de preuve: High

Pourquoi elle survient

Cholestyramine binds teriflunomide in the intestine, preventing reabsorption and enhancing fecal elimination.

Conduite à tenir

Avoid concurrent use unless a washout is intended; for accelerated elimination, use the labeled cholestyramine regimen. Otherwise choose another lipid-lowering agent.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cholestyramine with Leflunomide?

MediHelp rates the interaction as major. Cholestyramine and Leflunomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cholestyramine binds teriflunomide in the gut and interrupts its enterohepatic recirculation, causing a marked fall in plasma levels. This is exploited for rapid elimination after leflunomide toxicity, but unintended use reduces efficacy.

How serious is the interaction between Cholestyramine and Leflunomide?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use unless a washout is intended; for accelerated elimination, use the labeled cholestyramine regimen. Otherwise choose another lipid-lowering agent.

What other medicines interact with Leflunomide?

MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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