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Interactions médicamenteuses

Cisplatin + Dexamethasone-tobramycin

Gravité: Majeure

Cisplatin and Dexamethasone-tobramycin: major interaction.

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Résumé

Cisplatin and tobramycin are both nephrotoxic and ototoxic, so combined use can cause additive kidney injury and hearing loss. The risk is greater with systemic aminoglycoside use, existing renal impairment or dehydration.

Ce que signifie cette interaction, en termes simples

Cisplatin and Dexamethasone-tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cisplatin belongs to Oncology; Dexamethasone-tobramycin belongs to Anti Bacterial.

Niveau de preuve: High

Pourquoi elle survient

Additive proximal tubular toxicity and cochlear hair cell damage.

Conduite à tenir

Avoid concurrent systemic use where possible. If unavoidable, ensure hydration, monitor creatinine, electrolytes (magnesium) and hearing, and use tobramycin levels.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cisplatin with Dexamethasone-tobramycin?

MediHelp rates the interaction as major. Cisplatin and Dexamethasone-tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cisplatin and tobramycin are both nephrotoxic and ototoxic, so combined use can cause additive kidney injury and hearing loss. The risk is greater with systemic aminoglycoside use, existing renal impairment or dehydration.

How serious is the interaction between Cisplatin and Dexamethasone-tobramycin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent systemic use where possible. If unavoidable, ensure hydration, monitor creatinine, electrolytes (magnesium) and hearing, and use tobramycin levels.

What other medicines interact with Dexamethasone-tobramycin?

MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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