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Interactions médicamenteuses

Clarithromycin + Cobimetinib

Gravité: Majeure

Clarithromycin and Cobimetinib: major interaction.

Dernière mise à jour

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Résumé

Clarithromycin, a strong CYP3A4 inhibitor, markedly increases cobimetinib exposure and may raise the risk of adverse effects such as hemorrhage, serous retinopathy, rhabdomyolysis, and cardiomyopathy.

Ce que signifie cette interaction, en termes simples

Clarithromycin and Cobimetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Clarithromycin belongs to Anti Bacterial; Cobimetinib belongs to Oncology.

Niveau de preuve: High

Pourquoi elle survient

Clarithromycin inhibits CYP3A4-mediated metabolism of cobimetinib, greatly increasing its exposure.

Conduite à tenir

Avoid the combination and use a non-CYP3A4-inhibiting antibiotic such as azithromycin. If a strong inhibitor is short-term unavoidable, reduce cobimetinib dose per labeling and monitor closely.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Clarithromycin with Cobimetinib?

MediHelp rates the interaction as major. Clarithromycin and Cobimetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin, a strong CYP3A4 inhibitor, markedly increases cobimetinib exposure and may raise the risk of adverse effects such as hemorrhage, serous retinopathy, rhabdomyolysis, and cardiomyopathy.

How serious is the interaction between Clarithromycin and Cobimetinib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-CYP3A4-inhibiting antibiotic such as azithromycin. If a strong inhibitor is short-term unavoidable, reduce cobimetinib dose per labeling and monitor closely.

What other medicines interact with Clarithromycin?

MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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