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Interactions médicamenteuses

Clarithromycin + Ergotamine

Gravité: Contre-indiquée

Clarithromycin and Ergotamine: contraindicated interaction.

Dernière mise à jour Sources: US FDA label

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Résumé

Clarithromycin increases ergotamine concentrations and has been associated with acute ergot toxicity, including severe vasospasm and ischemia of the extremities, central nervous system and heart. Serious ischemic complications have been reported, sometimes after only a few doses. Concomitant use is contraindicated in product labeling.

Ce que signifie cette interaction, en termes simples

Clarithromycin and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Clarithromycin belongs to Anti Bacterial; Ergotamine belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Clarithromycin strongly inhibits CYP3A4, reducing the metabolism of ergotamine and causing excessive exposure and vasoconstriction.

Conduite à tenir

Do not combine; choose a non-interacting antibiotic such as azithromycin (weaker effect) or another class suited to the infection if an ergot is needed. Alternatively withhold ergotamine and treat migraine with a non-ergot agent while clarithromycin is given.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Références

Questions fréquentes

Can I take Clarithromycin with Ergotamine?

MediHelp rates the interaction as contraindicated. Clarithromycin and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin increases ergotamine concentrations and has been associated with acute ergot toxicity, including severe vasospasm and ischemia of the extremities, central nervous system and heart. Serious ischemic complications have been reported, sometimes after only a few doses. Concomitant use is contraindicated in product labeling.

How serious is the interaction between Clarithromycin and Ergotamine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose a non-interacting antibiotic such as azithromycin (weaker effect) or another class suited to the infection if an ergot is needed. Alternatively withhold ergotamine and treat migraine with a non-ergot agent while clarithromycin is given.

What other medicines interact with Ergotamine?

MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Cobicistat. The full list is on the Ergotamine page.

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