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Interactions médicamenteuses

Clarithromycin + Finerenone

Gravité: Contre-indiquée

Clarithromycin and Finerenone: contraindicated interaction.

Dernière mise à jour

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Résumé

Clarithromycin greatly increases finerenone exposure, which raises the risk of hyperkalemia and hypotension, as well as renal function decline. Labeling contraindicates strong CYP3A4 inhibitors.

Ce que signifie cette interaction, en termes simples

Clarithromycin and Finerenone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Clarithromycin belongs to Anti Bacterial; Finerenone belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Clarithromycin inhibits CYP3A4, the main metabolic pathway of finerenone.

Conduite à tenir

Do not coadminister; use an alternative antibiotic such as azithromycin, and check serum potassium if exposure occurs.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Clarithromycin with Finerenone?

MediHelp rates the interaction as contraindicated. Clarithromycin and Finerenone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin greatly increases finerenone exposure, which raises the risk of hyperkalemia and hypotension, as well as renal function decline. Labeling contraindicates strong CYP3A4 inhibitors.

How serious is the interaction between Clarithromycin and Finerenone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antibiotic such as azithromycin, and check serum potassium if exposure occurs.

What other medicines interact with Clarithromycin?

MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.

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