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Interactions médicamenteuses

Clarithromycin + Leniolisib

Gravité: Majeure

Clarithromycin and Leniolisib: major interaction.

Dernière mise à jour

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Résumé

Leniolisib is metabolized mainly by CYP3A4, so clarithromycin can increase its exposure and the risk of adverse effects.

Ce que signifie cette interaction, en termes simples

Clarithromycin and Leniolisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Clarithromycin belongs to Anti Bacterial; Leniolisib belongs to Miscellaneous.

Niveau de preuve: Moderate

Pourquoi elle survient

Strong CYP3A4 inhibition reduces leniolisib clearance.

Conduite à tenir

Avoid the combination and choose a non-inhibiting antibiotic. If unavoidable, monitor for leniolisib adverse effects.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Clarithromycin with Leniolisib?

MediHelp rates the interaction as major. Clarithromycin and Leniolisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Leniolisib is metabolized mainly by CYP3A4, so clarithromycin can increase its exposure and the risk of adverse effects.

How serious is the interaction between Clarithromycin and Leniolisib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-inhibiting antibiotic. If unavoidable, monitor for leniolisib adverse effects.

What other medicines interact with Clarithromycin?

MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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