Drug interactions
Clarithromycin + Leniolisib
Severity: Major
Clarithromycin and Leniolisib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib is metabolized mainly by CYP3A4, so clarithromycin can increase its exposure and the risk of adverse effects.
What this interaction means in plain words
Clarithromycin and Leniolisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Leniolisib belongs to Miscellaneous.
Why it happens
Strong CYP3A4 inhibition reduces leniolisib clearance.
What to do
Avoid the combination and choose a non-inhibiting antibiotic. If unavoidable, monitor for leniolisib adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Leniolisib
Frequently asked questions
Can I take Clarithromycin with Leniolisib?
MediHelp rates the interaction as major. Clarithromycin and Leniolisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Leniolisib is metabolized mainly by CYP3A4, so clarithromycin can increase its exposure and the risk of adverse effects.
How serious is the interaction between Clarithromycin and Leniolisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-inhibiting antibiotic. If unavoidable, monitor for leniolisib adverse effects.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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