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Interactions médicamenteuses

Clarithromycin + Paricalcitol

Gravité: Modérée

Clarithromycin and Paricalcitol: moderate interaction.

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Résumé

Paricalcitol is partly metabolized by CYP3A4, so clarithromycin may raise its exposure. This could lead to hypercalcemia or hyperphosphatemia, particularly with prolonged use.

Ce que signifie cette interaction, en termes simples

Clarithromycin and Paricalcitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Clarithromycin belongs to Anti Bacterial; Paricalcitol belongs to Musculoskeletal.

Niveau de preuve: Low

Pourquoi elle survient

Clarithromycin inhibits CYP3A4 metabolism of paricalcitol.

Conduite à tenir

Monitor serum calcium, phosphate and PTH during and after the antibiotic course, and lower the paricalcitol dose if hypercalcemia develops.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Clarithromycin with Paricalcitol?

MediHelp rates the interaction as moderate. Clarithromycin and Paricalcitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paricalcitol is partly metabolized by CYP3A4, so clarithromycin may raise its exposure. This could lead to hypercalcemia or hyperphosphatemia, particularly with prolonged use.

How serious is the interaction between Clarithromycin and Paricalcitol?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, phosphate and PTH during and after the antibiotic course, and lower the paricalcitol dose if hypercalcemia develops.

What other medicines interact with Clarithromycin?

MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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