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Interactions médicamenteuses

Clarithromycin + Pasireotide

Gravité: Majeure

Clarithromycin and Pasireotide: major interaction.

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Résumé

Both drugs can prolong the QT interval, and pasireotide also causes bradycardia. Together they may increase the risk of torsades de pointes, particularly with electrolyte disturbance or heart disease.

Ce que signifie cette interaction, en termes simples

Clarithromycin and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Clarithromycin belongs to Anti Bacterial; Pasireotide belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive QT prolongation, with pasireotide-induced bradycardia adding to the arrhythmic risk.

Conduite à tenir

Check ECG and electrolytes at baseline and correct potassium and magnesium deficits. Monitor QTc during co-therapy, or choose a non-QT-prolonging antibiotic.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Clarithromycin with Pasireotide?

MediHelp rates the interaction as major. Clarithromycin and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and pasireotide also causes bradycardia. Together they may increase the risk of torsades de pointes, particularly with electrolyte disturbance or heart disease.

How serious is the interaction between Clarithromycin and Pasireotide?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline and correct potassium and magnesium deficits. Monitor QTc during co-therapy, or choose a non-QT-prolonging antibiotic.

What other medicines interact with Clarithromycin?

MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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