Aller au contenu
MediHelp
MediHelp Référence médicamenteuse

Interactions médicamenteuses

Clomipramine + Phenelzine

Gravité: Contre-indiquée

Clomipramine and Phenelzine: contraindicated interaction.

Dernière mise à jour

Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.

Le contenu clinique de cette page n'est disponible qu'en anglais.

Résumé

Clomipramine is a potent serotonin and noradrenaline reuptake inhibitor, and phenelzine (an irreversible non-selective MAO inhibitor) blocks monoamine breakdown. Serotonin syndrome and hypertensive crisis are the main dangers.

Ce que signifie cette interaction, en termes simples

Clomipramine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Clomipramine belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Monoamine reuptake inhibition plus MAO inhibition

Conduite à tenir

Do not use together. Wait at least 14 days after stopping phenelzine before starting the other drug; leave about 2 weeks after stopping clomipramine before starting an irreversible MAOI.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Réservé aux membres Pro+

Débloquer la page complète

Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Clomipramine et Phenelzine, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
Créer un compte gratuit Se connecter

Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.

Questions fréquentes

Can I take Clomipramine with Phenelzine?

MediHelp rates the interaction as contraindicated. Clomipramine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clomipramine is a potent serotonin and noradrenaline reuptake inhibitor, and phenelzine (an irreversible non-selective MAO inhibitor) blocks monoamine breakdown. Serotonin syndrome and hypertensive crisis are the main dangers.

How serious is the interaction between Clomipramine and Phenelzine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Wait at least 14 days after stopping phenelzine before starting the other drug; leave about 2 weeks after stopping clomipramine before starting an irreversible MAOI.

What other medicines interact with Clomipramine?

MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

Télécharger surApp Store Disponible surGoogle Play

Parcourir de A à Z · Interactions médicamenteuses

Télécharger l'app Se connecter