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Interactions médicamenteuses

Clomipramine + Isocarboxazid

Gravité: Contre-indiquée

Clomipramine and Isocarboxazid: contraindicated interaction.

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Résumé

Clomipramine is a potent serotonin and noradrenaline reuptake inhibitor, and isocarboxazid (an irreversible non-selective MAO inhibitor) blocks monoamine breakdown. Serotonin syndrome and hypertensive crisis are the main dangers.

Ce que signifie cette interaction, en termes simples

Clomipramine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Clomipramine belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Monoamine reuptake inhibition plus MAO inhibition

Conduite à tenir

Do not use together. Wait at least 14 days after stopping isocarboxazid before starting the other drug; leave about 2 weeks after stopping clomipramine before starting an irreversible MAOI.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Clomipramine with Isocarboxazid?

MediHelp rates the interaction as contraindicated. Clomipramine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clomipramine is a potent serotonin and noradrenaline reuptake inhibitor, and isocarboxazid (an irreversible non-selective MAO inhibitor) blocks monoamine breakdown. Serotonin syndrome and hypertensive crisis are the main dangers.

How serious is the interaction between Clomipramine and Isocarboxazid?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Wait at least 14 days after stopping isocarboxazid before starting the other drug; leave about 2 weeks after stopping clomipramine before starting an irreversible MAOI.

What other medicines interact with Clomipramine?

MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.

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