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Interactions médicamenteuses

Clomipramine + Pentamidine

Gravité: Contre-indiquée

Clomipramine and Pentamidine: contraindicated interaction.

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Résumé

Both drugs can prolong the QT interval, and systemic pentamidine has been associated with torsades de pointes. Combined use raises the risk of life-threatening ventricular arrhythmia.

Ce que signifie cette interaction, en termes simples

Clomipramine and Pentamidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Clomipramine belongs to Central Nervous System; Pentamidine belongs to Anti Parasitic.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive prolongation of cardiac repolarization through effects on cardiac ion channels.

Conduite à tenir

Avoid concurrent use; choose a non-QT-prolonging alternative for one of the drugs. If pentamidine is essential, withhold clomipramine where feasible and monitor ECG and electrolytes.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Clomipramine with Pentamidine?

MediHelp rates the interaction as contraindicated. Clomipramine and Pentamidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can prolong the QT interval, and systemic pentamidine has been associated with torsades de pointes. Combined use raises the risk of life-threatening ventricular arrhythmia.

How serious is the interaction between Clomipramine and Pentamidine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; choose a non-QT-prolonging alternative for one of the drugs. If pentamidine is essential, withhold clomipramine where feasible and monitor ECG and electrolytes.

What other medicines interact with Clomipramine?

MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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