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Interactions médicamenteuses

Clozapine + Pimozide

Gravité: Contre-indiquée

Clozapine and Pimozide: contraindicated interaction.

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Résumé

Pimozide prolongs the QTc interval and is contraindicated with other QT-prolonging drugs, and clozapine can also lengthen the QTc interval and has been linked to ventricular arrhythmia. Together they raise the risk of torsades de pointes and sudden cardiac death.

Ce que signifie cette interaction, en termes simples

Clozapine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Clozapine belongs to Central Nervous System; Pimozide belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive QTc prolongation (pharmacodynamic)

Conduite à tenir

Do not co-administer; choose an alternative that does not prolong the QT interval.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Clozapine with Pimozide?

MediHelp rates the interaction as contraindicated. Clozapine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Pimozide prolongs the QTc interval and is contraindicated with other QT-prolonging drugs, and clozapine can also lengthen the QTc interval and has been linked to ventricular arrhythmia. Together they raise the risk of torsades de pointes and sudden cardiac death.

How serious is the interaction between Clozapine and Pimozide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; choose an alternative that does not prolong the QT interval.

What other medicines interact with Pimozide?

MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.

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