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Interactions médicamenteuses

Colchicine + Nirmatrelvir

Gravité: Contre-indiquée

Colchicine and Nirmatrelvir: contraindicated interaction.

Dernière mise à jour

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Résumé

Nirmatrelvir is used with ritonavir, which strongly inhibits CYP3A4 and P-glycoprotein, and can greatly increase colchicine exposure. This risks fatal colchicine toxicity including bone marrow suppression, multiorgan failure and neuromuscular toxicity, especially in renal or hepatic impairment.

Ce que signifie cette interaction, en termes simples

Colchicine and Nirmatrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Colchicine belongs to Genitourinary; Nirmatrelvir belongs to Anti Virals.

Niveau de preuve: High

Pourquoi elle survient

Inhibition of CYP3A4 and P-glycoprotein by the ritonavir-boosted regimen reduces colchicine clearance.

Conduite à tenir

Avoid during the course; withhold colchicine or use an alternative for the duration of treatment as advised by the labeling. In renal or hepatic impairment do not combine.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Colchicine with Nirmatrelvir?

MediHelp rates the interaction as contraindicated. Colchicine and Nirmatrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nirmatrelvir is used with ritonavir, which strongly inhibits CYP3A4 and P-glycoprotein, and can greatly increase colchicine exposure. This risks fatal colchicine toxicity including bone marrow suppression, multiorgan failure and neuromuscular toxicity, especially in renal or hepatic impairment.

How serious is the interaction between Colchicine and Nirmatrelvir?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during the course; withhold colchicine or use an alternative for the duration of treatment as advised by the labeling. In renal or hepatic impairment do not combine.

What other medicines interact with Colchicine?

MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.

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