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Interactions médicamenteuses

Cobicistat + Colchicine

Gravité: Contre-indiquée

Cobicistat and Colchicine: contraindicated interaction.

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Résumé

Cobicistat strongly inhibits CYP3A4 and P-glycoprotein, markedly increasing colchicine exposure. This can lead to life-threatening colchicine toxicity, and the combination is contraindicated in patients with renal or hepatic impairment.

Ce que signifie cette interaction, en termes simples

Cobicistat and Colchicine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Cobicistat belongs to Miscellaneous; Colchicine belongs to Genitourinary.

Niveau de preuve: High

Pourquoi elle survient

Inhibition of CYP3A4 and P-glycoprotein reduces colchicine metabolism and efflux.

Conduite à tenir

Do not use together in patients with renal or hepatic impairment. In others, reduce the colchicine dose substantially as per labeling and monitor for toxicity.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cobicistat with Colchicine?

MediHelp rates the interaction as contraindicated. Cobicistat and Colchicine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat strongly inhibits CYP3A4 and P-glycoprotein, markedly increasing colchicine exposure. This can lead to life-threatening colchicine toxicity, and the combination is contraindicated in patients with renal or hepatic impairment.

How serious is the interaction between Cobicistat and Colchicine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together in patients with renal or hepatic impairment. In others, reduce the colchicine dose substantially as per labeling and monitor for toxicity.

What other medicines interact with Colchicine?

MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cyclosporine, Ensitrelvir. The full list is on the Colchicine page.

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