Interactions médicamenteuses
Cyclosporine + Upadacitinib
Gravité: Contre-indiquée
Cyclosporine and Upadacitinib: contraindicated interaction.
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Résumé
Cyclosporine is a potent immunosuppressant, and combined with upadacitinib it increases the risk of serious infection and malignancy. Upadacitinib labeling advises against use with potent immunosuppressants such as cyclosporine.
Ce que signifie cette interaction, en termes simples
Cyclosporine and Upadacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Additive immunosuppression through calcineurin and JAK inhibition.
Conduite à tenir
Avoid the combination. Choose a regimen that does not pair a JAK inhibitor with cyclosporine.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Upadacitinib
- Abrocitinib + Upadacitinib Contre-indiquée
- Adenovirus types 4 and 7 live + Upadacitinib Contre-indiquée
- Baricitinib + Upadacitinib Contre-indiquée
- Bcg vaccine live + Upadacitinib Contre-indiquée
- Dengue vaccine + Upadacitinib Contre-indiquée
- Influenza virus vaccine quadrivalent intranasal + Upadacitinib Contre-indiquée
Questions fréquentes
Can I take Cyclosporine with Upadacitinib?
MediHelp rates the interaction as contraindicated. Cyclosporine and Upadacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cyclosporine is a potent immunosuppressant, and combined with upadacitinib it increases the risk of serious infection and malignancy. Upadacitinib labeling advises against use with potent immunosuppressants such as cyclosporine.
How serious is the interaction between Cyclosporine and Upadacitinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Choose a regimen that does not pair a JAK inhibitor with cyclosporine.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
