Interactions médicamenteuses
Baricitinib + Upadacitinib
Gravité: Contre-indiquée
Baricitinib and Upadacitinib: contraindicated interaction.
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Résumé
Baricitinib and upadacitinib are both JAK inhibitors, so using them together duplicates therapy without proven benefit. Exposure to JAK-related adverse effects such as serious infection, thrombosis, cytopenias and lipid rise is doubled.
Ce que signifie cette interaction, en termes simples
Baricitinib and Upadacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Baricitinib belongs to Musculoskeletal; Upadacitinib belongs to Musculoskeletal.
Pourquoi elle survient
Therapeutic duplication of JAK inhibition
Conduite à tenir
Do not combine; if switching between JAK inhibitors, stop the first agent before starting the second.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contre-indiquée
- Baricitinib + Bcg vaccine live Contre-indiquée
- Baricitinib + Tofacitinib Contre-indiquée
- Abatacept + Baricitinib Majeure
- Adalimumab + Baricitinib Majeure
- Ado-trastuzumab + Baricitinib Majeure
Autres interactions de Upadacitinib
- Abrocitinib + Upadacitinib Contre-indiquée
- Adenovirus types 4 and 7 live + Upadacitinib Contre-indiquée
- Bcg vaccine live + Upadacitinib Contre-indiquée
- Cyclosporine + Upadacitinib Contre-indiquée
- Dengue vaccine + Upadacitinib Contre-indiquée
- Influenza virus vaccine quadrivalent intranasal + Upadacitinib Contre-indiquée
Questions fréquentes
Can I take Baricitinib with Upadacitinib?
MediHelp rates the interaction as contraindicated. Baricitinib and Upadacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Baricitinib and upadacitinib are both JAK inhibitors, so using them together duplicates therapy without proven benefit. Exposure to JAK-related adverse effects such as serious infection, thrombosis, cytopenias and lipid rise is doubled.
How serious is the interaction between Baricitinib and Upadacitinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; if switching between JAK inhibitors, stop the first agent before starting the second.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
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