Interactions médicamenteuses
Dabigatran + Dipyridamole
Gravité: Majeure
Dabigatran and Dipyridamole: major interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Dipyridamole adds antiplatelet activity to dabigatran's anticoagulation and, as a P-glycoprotein inhibitor, may increase dabigatran exposure. Both effects raise bleeding risk, especially in renal impairment.
Ce que signifie cette interaction, en termes simples
Dabigatran and Dipyridamole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Additive effects on hemostasis plus P-glycoprotein inhibition by dipyridamole that raises dabigatran levels.
Conduite à tenir
Monitor for bleeding and renal function. Avoid the combination in patients with reduced creatinine clearance, following dabigatran labeling for P-gp inhibitors.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Dabigatran et Dipyridamole, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 7 jours sur le web. Sans carte.
Autres interactions de Dipyridamole
- Dipyridamole + Riociguat Contre-indiquée
- Adenosine + Dipyridamole Majeure
- Betrixaban + Dipyridamole Majeure
- Dipyridamole + Regadenoson Majeure
- Dipyridamole + Venetoclax Majeure
- Dipyridamole + Vorapaxar Majeure
Questions fréquentes
Can I take Dabigatran with Dipyridamole?
MediHelp rates the interaction as major. Dabigatran and Dipyridamole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dipyridamole adds antiplatelet activity to dabigatran's anticoagulation and, as a P-glycoprotein inhibitor, may increase dabigatran exposure. Both effects raise bleeding risk, especially in renal impairment.
How serious is the interaction between Dabigatran and Dipyridamole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and renal function. Avoid the combination in patients with reduced creatinine clearance, following dabigatran labeling for P-gp inhibitors.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
