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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Dipyridamole + Venetoclax

Gravité: Majeure

Dipyridamole and Venetoclax: major interaction.

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Résumé

Dipyridamole inhibits P-glycoprotein, which may increase venetoclax exposure and the risk of neutropenia and tumor lysis syndrome.

Ce que signifie cette interaction, en termes simples

Dipyridamole and Venetoclax can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Dipyridamole belongs to Cardiovascular; Venetoclax belongs to Miscellaneous.

Niveau de preuve: Moderate

Pourquoi elle survient

Dipyridamole inhibits P-glycoprotein efflux of venetoclax, increasing its systemic exposure.

Conduite à tenir

Avoid if possible; otherwise reduce the venetoclax dose by at least 50% as per labeling and monitor blood counts and tumor lysis parameters.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dipyridamole with Venetoclax?

MediHelp rates the interaction as major. Dipyridamole and Venetoclax can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dipyridamole inhibits P-glycoprotein, which may increase venetoclax exposure and the risk of neutropenia and tumor lysis syndrome.

How serious is the interaction between Dipyridamole and Venetoclax?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce the venetoclax dose by at least 50% as per labeling and monitor blood counts and tumor lysis parameters.

What other medicines interact with Dipyridamole?

MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.

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