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Interactions médicamenteuses

Darunavir + Simvastatin

Gravité: Contre-indiquée

Darunavir and Simvastatin: contraindicated interaction.

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Résumé

Darunavir, usually given with ritonavir or cobicistat, substantially raises simvastatin concentrations and the risk of rhabdomyolysis. The combination is contraindicated in labeling.

Ce que signifie cette interaction, en termes simples

Darunavir and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Darunavir belongs to Anti Virals; Simvastatin belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Darunavir and its pharmacokinetic booster inhibit CYP3A4, blocking first-pass and hepatic metabolism of simvastatin.

Conduite à tenir

Do not co-administer; stop simvastatin during darunavir therapy and use an alternative such as pravastatin or low-dose atorvastatin or rosuvastatin with monitoring.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Darunavir with Simvastatin?

MediHelp rates the interaction as contraindicated. Darunavir and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Darunavir, usually given with ritonavir or cobicistat, substantially raises simvastatin concentrations and the risk of rhabdomyolysis. The combination is contraindicated in labeling.

How serious is the interaction between Darunavir and Simvastatin?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; stop simvastatin during darunavir therapy and use an alternative such as pravastatin or low-dose atorvastatin or rosuvastatin with monitoring.

What other medicines interact with Simvastatin?

MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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