Drug interactions
Darunavir + Simvastatin
Severity: Contraindicated
Darunavir and Simvastatin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually given with ritonavir or cobicistat, substantially raises simvastatin concentrations and the risk of rhabdomyolysis. The combination is contraindicated in labeling.
What this interaction means in plain words
Darunavir and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Darunavir belongs to Anti Virals; Simvastatin belongs to Cardiovascular.
Why it happens
Darunavir and its pharmacokinetic booster inhibit CYP3A4, blocking first-pass and hepatic metabolism of simvastatin.
What to do
Do not co-administer; stop simvastatin during darunavir therapy and use an alternative such as pravastatin or low-dose atorvastatin or rosuvastatin with monitoring.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Simvastatin?
MediHelp rates the interaction as contraindicated. Darunavir and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Darunavir, usually given with ritonavir or cobicistat, substantially raises simvastatin concentrations and the risk of rhabdomyolysis. The combination is contraindicated in labeling.
How serious is the interaction between Darunavir and Simvastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; stop simvastatin during darunavir therapy and use an alternative such as pravastatin or low-dose atorvastatin or rosuvastatin with monitoring.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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