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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Deferiprone + Vorinostat

Gravité: Majeure

Deferiprone and Vorinostat: major interaction.

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Résumé

Deferiprone can cause agranulocytosis and neutropenia, and vorinostat commonly causes cytopenias, particularly thrombocytopenia and sometimes neutropenia. Combined use may increase the risk of severe bone marrow suppression and infection.

Ce que signifie cette interaction, en termes simples

Deferiprone and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Deferiprone belongs to Miscellaneous; Vorinostat belongs to Oncology.

Niveau de preuve: Low

Pourquoi elle survient

Additive pharmacodynamic myelosuppressive effects.

Conduite à tenir

Avoid concurrent use if an alternative is available. If unavoidable, monitor absolute neutrophil count and platelets frequently and stop deferiprone if neutropenia occurs.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Deferiprone with Vorinostat?

MediHelp rates the interaction as major. Deferiprone and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferiprone can cause agranulocytosis and neutropenia, and vorinostat commonly causes cytopenias, particularly thrombocytopenia and sometimes neutropenia. Combined use may increase the risk of severe bone marrow suppression and infection.

How serious is the interaction between Deferiprone and Vorinostat?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if an alternative is available. If unavoidable, monitor absolute neutrophil count and platelets frequently and stop deferiprone if neutropenia occurs.

What other medicines interact with Deferiprone?

MediHelp also lists interactions of Deferiprone with, for example, Clozapine, Abemaciclib, Acalabrutinib. The full list is on the Deferiprone page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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