Drug interactions
Deferiprone + Vorinostat
Severity: Major
Deferiprone and Vorinostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferiprone can cause agranulocytosis and neutropenia, and vorinostat commonly causes cytopenias, particularly thrombocytopenia and sometimes neutropenia. Combined use may increase the risk of severe bone marrow suppression and infection.
What this interaction means in plain words
Deferiprone and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferiprone belongs to Miscellaneous; Vorinostat belongs to Oncology.
Why it happens
Additive pharmacodynamic myelosuppressive effects.
What to do
Avoid concurrent use if an alternative is available. If unavoidable, monitor absolute neutrophil count and platelets frequently and stop deferiprone if neutropenia occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Deferiprone with Vorinostat?
MediHelp rates the interaction as major. Deferiprone and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferiprone can cause agranulocytosis and neutropenia, and vorinostat commonly causes cytopenias, particularly thrombocytopenia and sometimes neutropenia. Combined use may increase the risk of severe bone marrow suppression and infection.
How serious is the interaction between Deferiprone and Vorinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if an alternative is available. If unavoidable, monitor absolute neutrophil count and platelets frequently and stop deferiprone if neutropenia occurs.
What other medicines interact with Deferiprone?
MediHelp also lists interactions of Deferiprone with, for example, Clozapine, Abemaciclib, Acalabrutinib. The full list is on the Deferiprone page.
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