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Interactions médicamenteuses

Dengue vaccine + Liposomal doxorubicin

Gravité: Contre-indiquée

Dengue vaccine and Liposomal doxorubicin: contraindicated interaction.

Dernière mise à jour

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Résumé

Dengue vaccine is a live attenuated vaccine, and myelosuppressive chemotherapy may blunt the immune response and allow vaccine virus replication. Immunocompromised patients are at risk of disseminated vaccine infection.

Ce que signifie cette interaction, en termes simples

Dengue vaccine and Liposomal doxorubicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Niveau de preuve: Moderate

Pourquoi elle survient

Chemotherapy-induced immunosuppression impairs vaccine response and permits uncontrolled replication of live vaccine virus.

Conduite à tenir

Do not give the live dengue vaccine during chemotherapy; defer until immune recovery as advised by the oncology team.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dengue vaccine with Liposomal doxorubicin?

MediHelp rates the interaction as contraindicated. Dengue vaccine and Liposomal doxorubicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dengue vaccine is a live attenuated vaccine, and myelosuppressive chemotherapy may blunt the immune response and allow vaccine virus replication. Immunocompromised patients are at risk of disseminated vaccine infection.

How serious is the interaction between Dengue vaccine and Liposomal doxorubicin?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the live dengue vaccine during chemotherapy; defer until immune recovery as advised by the oncology team.

What other medicines interact with Liposomal doxorubicin?

MediHelp also lists interactions of Liposomal doxorubicin with, for example, Belatacept, Cyclosporine, Dronedarone. The full list is on the Liposomal doxorubicin page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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