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Interactions médicamenteuses

Dihydroergotamine + Erythromycin lactobionate

Gravité: Contre-indiquée

Dihydroergotamine and Erythromycin lactobionate: contraindicated interaction.

Dernière mise à jour Sources: US FDA label

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Résumé

Erythromycin raises dihydroergotamine concentrations, which can cause ergotism with severe peripheral and cerebral vasospasm and ischemia. Cases of limb and organ ischemia have been reported with CYP3A4 inhibitors and ergots.

Ce que signifie cette interaction, en termes simples

Dihydroergotamine and Erythromycin lactobionate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Dihydroergotamine belongs to Central Nervous System; Erythromycin lactobionate belongs to Anti Bacterial.

Niveau de preuve: High

Pourquoi elle survient

Erythromycin inhibits CYP3A4-mediated metabolism of dihydroergotamine.

Conduite à tenir

Do not use together; choose a non-macrolide antibiotic such as one without CYP3A4 inhibition, or another migraine therapy.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Références

Questions fréquentes

Can I take Dihydroergotamine with Erythromycin lactobionate?

MediHelp rates the interaction as contraindicated. Dihydroergotamine and Erythromycin lactobionate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Erythromycin raises dihydroergotamine concentrations, which can cause ergotism with severe peripheral and cerebral vasospasm and ischemia. Cases of limb and organ ischemia have been reported with CYP3A4 inhibitors and ergots.

How serious is the interaction between Dihydroergotamine and Erythromycin lactobionate?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose a non-macrolide antibiotic such as one without CYP3A4 inhibition, or another migraine therapy.

What other medicines interact with Erythromycin lactobionate?

MediHelp also lists interactions of Erythromycin lactobionate with, for example, Cisapride, Dronedarone, Eletriptan. The full list is on the Erythromycin lactobionate page.

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