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Interactions médicamenteuses

Dihydroergotamine + Eletriptan

Gravité: Contre-indiquée

Dihydroergotamine and Eletriptan: contraindicated interaction.

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Résumé

Eletriptan and dihydroergotamine both constrict blood vessels, and together they may produce prolonged vasospasm. Cardiac and cerebral ischemia are the concern.

Ce que signifie cette interaction, en termes simples

Dihydroergotamine and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Dihydroergotamine belongs to Central Nervous System; Eletriptan belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Additive vasoconstriction via 5-HT1B/1D agonism and ergot vascular receptor effects; dihydroergotamine is also a CYP3A4 substrate.

Conduite à tenir

Avoid together and separate by at least 24 hours. Use only one agent per attack.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dihydroergotamine with Eletriptan?

MediHelp rates the interaction as contraindicated. Dihydroergotamine and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Eletriptan and dihydroergotamine both constrict blood vessels, and together they may produce prolonged vasospasm. Cardiac and cerebral ischemia are the concern.

How serious is the interaction between Dihydroergotamine and Eletriptan?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid together and separate by at least 24 hours. Use only one agent per attack.

What other medicines interact with Eletriptan?

MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.

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