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Interactions médicamenteuses

Dihydroergotamine + Dopamine

Gravité: Contre-indiquée

Dihydroergotamine and Dopamine: contraindicated interaction.

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Résumé

Both agents cause vasoconstriction, and combined use can produce severe peripheral and cerebral vasospasm with marked hypertension. Ischemic complications have been described with ergot alkaloids and pressor agents.

Ce que signifie cette interaction, en termes simples

Dihydroergotamine and Dopamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Dihydroergotamine belongs to Central Nervous System; Dopamine belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive alpha-adrenergic and direct vascular smooth muscle vasoconstriction.

Conduite à tenir

Avoid combining; use a non-ergot therapy for migraine in patients needing dopamine. If it occurs, monitor perfusion and blood pressure closely.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dihydroergotamine with Dopamine?

MediHelp rates the interaction as contraindicated. Dihydroergotamine and Dopamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents cause vasoconstriction, and combined use can produce severe peripheral and cerebral vasospasm with marked hypertension. Ischemic complications have been described with ergot alkaloids and pressor agents.

How serious is the interaction between Dihydroergotamine and Dopamine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; use a non-ergot therapy for migraine in patients needing dopamine. If it occurs, monitor perfusion and blood pressure closely.

What other medicines interact with Dopamine?

MediHelp also lists interactions of Dopamine with, for example, Dihydroergotamine intranasal, Selegiline transdermal, Amitriptyline. The full list is on the Dopamine page.

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