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Interactions médicamenteuses

Dihydroergotamine + Frovatriptan

Gravité: Contre-indiquée

Dihydroergotamine and Frovatriptan: contraindicated interaction.

Dernière mise à jour

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Résumé

Both drugs are vasoconstrictors acting on serotonin receptors, and together they can cause prolonged vasospasm. Cases of peripheral and cerebral ischemia are described with triptan-ergot combinations.

Ce que signifie cette interaction, en termes simples

Dihydroergotamine and Frovatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Dihydroergotamine belongs to Central Nervous System; Frovatriptan belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive vasoconstriction through 5-HT1B/1D agonism and ergot-mediated vascular receptor effects.

Conduite à tenir

Do not use within 24 hours of each other. Choose one agent for each migraine attack.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dihydroergotamine with Frovatriptan?

MediHelp rates the interaction as contraindicated. Dihydroergotamine and Frovatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs are vasoconstrictors acting on serotonin receptors, and together they can cause prolonged vasospasm. Cases of peripheral and cerebral ischemia are described with triptan-ergot combinations.

How serious is the interaction between Dihydroergotamine and Frovatriptan?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use within 24 hours of each other. Choose one agent for each migraine attack.

What other medicines interact with Frovatriptan?

MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Eletriptan. The full list is on the Frovatriptan page.

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