Interactions médicamenteuses
Dihydroergotamine intranasal + Nitroglycerin
Gravité: Majeure
Dihydroergotamine intranasal and Nitroglycerin: major interaction.
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Résumé
Dihydroergotamine causes vasoconstriction that opposes nitroglycerin's vasodilation and may worsen myocardial ischemia. Nitrates may also raise ergot bioavailability, increasing vasospasm risk. Patients with angina are particularly at risk.
Ce que signifie cette interaction, en termes simples
Dihydroergotamine intranasal and Nitroglycerin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Opposing vasoactive effects, with possible increased dihydroergotamine exposure caused by nitrates.
Conduite à tenir
Avoid dihydroergotamine in patients needing nitrates for coronary disease and use an alternative migraine therapy. If both are given, monitor for chest pain and ischemic symptoms.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Nitroglycerin
- Avanafil + Nitroglycerin Contre-indiquée
- Nitroglycerin + Riociguat Contre-indiquée
- Nitroglycerin + Sildenafil Contre-indiquée
- Nitroglycerin + Tadalafil Contre-indiquée
- Nitroglycerin + Vardenafil Contre-indiquée
- Dihydroergotamine + Nitroglycerin Majeure
Questions fréquentes
Can I take Dihydroergotamine intranasal with Nitroglycerin?
MediHelp rates the interaction as major. Dihydroergotamine intranasal and Nitroglycerin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dihydroergotamine causes vasoconstriction that opposes nitroglycerin's vasodilation and may worsen myocardial ischemia. Nitrates may also raise ergot bioavailability, increasing vasospasm risk. Patients with angina are particularly at risk.
How serious is the interaction between Dihydroergotamine intranasal and Nitroglycerin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid dihydroergotamine in patients needing nitrates for coronary disease and use an alternative migraine therapy. If both are given, monitor for chest pain and ischemic symptoms.
What other medicines interact with Nitroglycerin?
MediHelp also lists interactions of Nitroglycerin with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Nitroglycerin page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
