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Interactions médicamenteuses

Nitroglycerin + Tadalafil

Gravité: Contre-indiquée

Nitroglycerin and Tadalafil: contraindicated interaction.

Dernière mise à jour Sources: US FDA label

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Résumé

Tadalafil potentiates the hypotensive effect of nitrates and the combination can cause severe, potentially fatal hypotension, syncope or myocardial ischaemia. Because of tadalafil's long half-life, the risk persists for a prolonged period after a dose. Use is contraindicated in labeling.

Ce que signifie cette interaction, en termes simples

Nitroglycerin and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Nitroglycerin belongs to Cardiovascular; Tadalafil belongs to Genitourinary.

Niveau de preuve: High

Pourquoi elle survient

PDE5 inhibition prevents cGMP breakdown while nitroglycerin raises cGMP via nitric oxide, producing exaggerated vasodilation.

Conduite à tenir

Do not use nitrates in patients who have taken tadalafil in the previous 48 hours. If a nitrate is needed urgently after that interval, use it only under close medical supervision.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Références

Questions fréquentes

Can I take Nitroglycerin with Tadalafil?

MediHelp rates the interaction as contraindicated. Nitroglycerin and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tadalafil potentiates the hypotensive effect of nitrates and the combination can cause severe, potentially fatal hypotension, syncope or myocardial ischaemia. Because of tadalafil's long half-life, the risk persists for a prolonged period after a dose. Use is contraindicated in labeling.

How serious is the interaction between Nitroglycerin and Tadalafil?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use nitrates in patients who have taken tadalafil in the previous 48 hours. If a nitrate is needed urgently after that interval, use it only under close medical supervision.

What other medicines interact with Tadalafil?

MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.

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