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Interactions médicamenteuses

Disopyramide + Trimipramine

Gravité: Contre-indiquée

Disopyramide and Trimipramine: contraindicated interaction.

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Résumé

Disopyramide prolongs the QT interval and has negative inotropic and anticholinergic effects that overlap with trimipramine. Combined use raises the risk of torsades de pointes and conduction disturbance.

Ce que signifie cette interaction, en termes simples

Disopyramide and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Disopyramide belongs to Cardiovascular; Trimipramine belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive QT prolongation and sodium channel blockade, plus additive anticholinergic effects.

Conduite à tenir

Avoid the combination and use alternatives. If unavoidable, monitor ECG and electrolytes closely.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Disopyramide with Trimipramine?

MediHelp rates the interaction as contraindicated. Disopyramide and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Disopyramide prolongs the QT interval and has negative inotropic and anticholinergic effects that overlap with trimipramine. Combined use raises the risk of torsades de pointes and conduction disturbance.

How serious is the interaction between Disopyramide and Trimipramine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use alternatives. If unavoidable, monitor ECG and electrolytes closely.

What other medicines interact with Trimipramine?

MediHelp also lists interactions of Trimipramine with, for example, Dofetilide, Ibutilide, Isocarboxazid. The full list is on the Trimipramine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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