Drug interactions
Disopyramide + Trimipramine
Severity: Contraindicated
Disopyramide and Trimipramine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide prolongs the QT interval and has negative inotropic and anticholinergic effects that overlap with trimipramine. Combined use raises the risk of torsades de pointes and conduction disturbance.
What this interaction means in plain words
Disopyramide and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Disopyramide belongs to Cardiovascular; Trimipramine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and sodium channel blockade, plus additive anticholinergic effects.
What to do
Avoid the combination and use alternatives. If unavoidable, monitor ECG and electrolytes closely.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Disopyramide and Trimipramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Trimipramine
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
- Pimozide + Trimipramine Contraindicated
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Trimipramine?
MediHelp rates the interaction as contraindicated. Disopyramide and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Disopyramide prolongs the QT interval and has negative inotropic and anticholinergic effects that overlap with trimipramine. Combined use raises the risk of torsades de pointes and conduction disturbance.
How serious is the interaction between Disopyramide and Trimipramine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use alternatives. If unavoidable, monitor ECG and electrolytes closely.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Dofetilide, Ibutilide, Isocarboxazid. The full list is on the Trimipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
