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Interactions médicamenteuses

Phenelzine + Trimipramine

Gravité: Contre-indiquée

Phenelzine and Trimipramine: contraindicated interaction.

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Résumé

Combining a tricyclic antidepressant with a nonselective MAOI can cause serotonin syndrome and hypertensive crisis. Reactions can be severe and life-threatening.

Ce que signifie cette interaction, en termes simples

Phenelzine and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Phenelzine belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

MAO inhibition combined with tricyclic reuptake inhibition causes excess serotonergic and noradrenergic activity.

Conduite à tenir

Do not use together. Allow a washout of at least 14 days after stopping phenelzine before trimipramine, and an appropriate interval in the other direction.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Phenelzine with Trimipramine?

MediHelp rates the interaction as contraindicated. Phenelzine and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining a tricyclic antidepressant with a nonselective MAOI can cause serotonin syndrome and hypertensive crisis. Reactions can be severe and life-threatening.

How serious is the interaction between Phenelzine and Trimipramine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Allow a washout of at least 14 days after stopping phenelzine before trimipramine, and an appropriate interval in the other direction.

What other medicines interact with Trimipramine?

MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.

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