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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Efavirenz + Lomitapide

Gravité: Contre-indiquée

Efavirenz and Lomitapide: contraindicated interaction.

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Résumé

Lomitapide is a sensitive CYP3A4 substrate and exposure can rise markedly with interacting drugs, increasing hepatotoxicity and gastrointestinal adverse effects. Efavirenz is a mixed CYP3A4 modulator and the net effect is uncertain, but the label restricts such combinations.

Ce que signifie cette interaction, en termes simples

Efavirenz and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Efavirenz belongs to Anti Virals; Lomitapide belongs to Cardiovascular.

Niveau de preuve: Low

Pourquoi elle survient

Efavirenz modulation of CYP3A4 alters lomitapide metabolism, with potential for increased exposure.

Conduite à tenir

Avoid the combination and choose a different lipid-lowering strategy or antiretroviral. If lomitapide is essential, monitor liver enzymes closely.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Efavirenz with Lomitapide?

MediHelp rates the interaction as contraindicated. Efavirenz and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lomitapide is a sensitive CYP3A4 substrate and exposure can rise markedly with interacting drugs, increasing hepatotoxicity and gastrointestinal adverse effects. Efavirenz is a mixed CYP3A4 modulator and the net effect is uncertain, but the label restricts such combinations.

How serious is the interaction between Efavirenz and Lomitapide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a different lipid-lowering strategy or antiretroviral. If lomitapide is essential, monitor liver enzymes closely.

What other medicines interact with Efavirenz?

MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.

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