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Interactions médicamenteuses

Crizotinib + Lomitapide

Gravité: Contre-indiquée

Crizotinib and Lomitapide: contraindicated interaction.

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Résumé

Crizotinib is a moderate CYP3A4 inhibitor and lomitapide is a sensitive CYP3A4 substrate, so exposure to lomitapide can rise markedly. This increases the risk of hepatotoxicity and gastrointestinal adverse effects.

Ce que signifie cette interaction, en termes simples

Crizotinib and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Crizotinib belongs to Oncology; Lomitapide belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Crizotinib inhibits CYP3A4, reducing first-pass and systemic metabolism of lomitapide.

Conduite à tenir

Avoid the combination; labeling for lomitapide advises against moderate and strong CYP3A4 inhibitors. Use an alternative lipid-lowering strategy during crizotinib treatment.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Crizotinib with Lomitapide?

MediHelp rates the interaction as contraindicated. Crizotinib and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Crizotinib is a moderate CYP3A4 inhibitor and lomitapide is a sensitive CYP3A4 substrate, so exposure to lomitapide can rise markedly. This increases the risk of hepatotoxicity and gastrointestinal adverse effects.

How serious is the interaction between Crizotinib and Lomitapide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; labeling for lomitapide advises against moderate and strong CYP3A4 inhibitors. Use an alternative lipid-lowering strategy during crizotinib treatment.

What other medicines interact with Crizotinib?

MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lonafarnib, Pimozide. The full list is on the Crizotinib page.

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