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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Diltiazem + Lomitapide

Gravité: Contre-indiquée

Diltiazem and Lomitapide: contraindicated interaction.

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Résumé

Diltiazem is a moderate CYP3A4 inhibitor and can raise lomitapide exposure several-fold. Higher lomitapide levels increase the risk of hepatotoxicity and gastrointestinal adverse effects. Labeling for lomitapide prohibits use with moderate and strong CYP3A4 inhibitors.

Ce que signifie cette interaction, en termes simples

Diltiazem and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Diltiazem belongs to Cardiovascular; Lomitapide belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Diltiazem inhibits CYP3A4-mediated first-pass and hepatic metabolism of lomitapide, markedly increasing its plasma concentration.

Conduite à tenir

Do not co-administer; choose a different antihypertensive or antianginal that does not inhibit CYP3A4. Monitor liver enzymes if lomitapide continues with an alternative.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Diltiazem with Lomitapide?

MediHelp rates the interaction as contraindicated. Diltiazem and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Diltiazem is a moderate CYP3A4 inhibitor and can raise lomitapide exposure several-fold. Higher lomitapide levels increase the risk of hepatotoxicity and gastrointestinal adverse effects. Labeling for lomitapide prohibits use with moderate and strong CYP3A4 inhibitors.

How serious is the interaction between Diltiazem and Lomitapide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; choose a different antihypertensive or antianginal that does not inhibit CYP3A4. Monitor liver enzymes if lomitapide continues with an alternative.

What other medicines interact with Diltiazem?

MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lonafarnib. The full list is on the Diltiazem page.

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