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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Eliglustat + Posaconazole

Gravité: Contre-indiquée

Eliglustat and Posaconazole: contraindicated interaction.

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Résumé

Posaconazole increases eliglustat concentrations, which may prolong PR, QRS and QT intervals and cause arrhythmias. The effect is greater in CYP2D6 poor or intermediate metabolizers and when a CYP2D6 inhibitor is also taken.

Ce que signifie cette interaction, en termes simples

Eliglustat and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Eliglustat belongs to Miscellaneous; Posaconazole belongs to Anti Fungals.

Niveau de preuve: High

Pourquoi elle survient

Posaconazole inhibits CYP3A4, a secondary eliglustat clearance pathway that becomes critical when CYP2D6 activity is low or inhibited.

Conduite à tenir

Avoid in CYP2D6 poor or intermediate metabolizers and with any additional CYP2D6 inhibitor. In extensive metabolizers, follow labeling with a reduced eliglustat dose and ECG monitoring, or choose an alternative antifungal.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Eliglustat with Posaconazole?

MediHelp rates the interaction as contraindicated. Eliglustat and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Posaconazole increases eliglustat concentrations, which may prolong PR, QRS and QT intervals and cause arrhythmias. The effect is greater in CYP2D6 poor or intermediate metabolizers and when a CYP2D6 inhibitor is also taken.

How serious is the interaction between Eliglustat and Posaconazole?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in CYP2D6 poor or intermediate metabolizers and with any additional CYP2D6 inhibitor. In extensive metabolizers, follow labeling with a reduced eliglustat dose and ECG monitoring, or choose an alternative antifungal.

What other medicines interact with Posaconazole?

MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.

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