Interactions médicamenteuses
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lamivudine
Gravité: Contre-indiquée
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lamivudine: contraindicated interaction.
Dernière mise à jour
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Résumé
This fixed-dose product already contains emtricitabine, which is closely related to lamivudine, so adding lamivudine duplicates the same cytosine analogue activity. This provides no added benefit, gives overlapping resistance selection, and raises the toxicity burden.
Ce que signifie cette interaction, en termes simples
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lamivudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Therapeutic duplication: lamivudine and emtricitabine are both cytidine analogues sharing the same target and resistance pathway.
Conduite à tenir
Do not combine; the single-tablet regimen is complete and should not be given with other antiretrovirals. Stop lamivudine if the regimen is used.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Lamivudine
Questions fréquentes
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Lamivudine?
MediHelp rates the interaction as contraindicated. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lamivudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. This fixed-dose product already contains emtricitabine, which is closely related to lamivudine, so adding lamivudine duplicates the same cytosine analogue activity. This provides no added benefit, gives overlapping resistance selection, and raises the toxicity burden.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lamivudine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; the single-tablet regimen is complete and should not be given with other antiretrovirals. Stop lamivudine if the regimen is used.
What other medicines interact with Lamivudine?
MediHelp also lists interactions of Lamivudine with, for example, Atidarsagene autotemcel, Betibeglogene autotemcel, Elivaldogene autotemcel. The full list is on the Lamivudine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
