Interactions médicamenteuses
Enasidenib + Ethinyl estradiol-norgestimate
Gravité: Modérée
Enasidenib and Ethinyl estradiol-norgestimate: moderate interaction.
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Résumé
Enasidenib may alter exposure to hormonal contraceptives, and the direction and size of the change are not well defined. A reduction could compromise contraceptive efficacy, which matters because enasidenib is teratogenic.
Ce que signifie cette interaction, en termes simples
Enasidenib and Ethinyl estradiol-norgestimate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enasidenib belongs to Oncology; Ethinyl estradiol-norgestimate belongs to Endocrine.
Pourquoi elle survient
The mechanism is not established; enasidenib may modulate CYP enzymes or transporters involved in contraceptive disposition.
Conduite à tenir
Advise an additional non-hormonal barrier method during enasidenib therapy. Do not rely solely on hormonal contraception.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contre-indiquée
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contre-indiquée
- Ethinyl estradiol-norgestimate + Tranexamic acid Contre-indiquée
- Aminocaproic acid + Ethinyl estradiol-norgestimate Majeure
- Amobarbital + Ethinyl estradiol-norgestimate Majeure
- Anastrozole + Ethinyl estradiol-norgestimate Majeure
Autres interactions de Enasidenib
Questions fréquentes
Can I take Enasidenib with Ethinyl estradiol-norgestimate?
MediHelp rates the interaction as moderate. Enasidenib and Ethinyl estradiol-norgestimate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enasidenib may alter exposure to hormonal contraceptives, and the direction and size of the change are not well defined. A reduction could compromise contraceptive efficacy, which matters because enasidenib is teratogenic.
How serious is the interaction between Enasidenib and Ethinyl estradiol-norgestimate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal barrier method during enasidenib therapy. Do not rely solely on hormonal contraception.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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