Interactions médicamenteuses
Enasidenib + Levonorgestrel
Gravité: Modérée
Enasidenib and Levonorgestrel: moderate interaction.
Dernière mise à jour
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Résumé
Enasidenib may induce CYP3A4 and alter hormonal contraceptive concentrations, and the labeling advises that its effect on contraceptives is uncertain. Reduced efficacy is possible. Enasidenib also carries embryo-fetal risk, making reliable contraception important.
Ce que signifie cette interaction, en termes simples
Enasidenib and Levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enasidenib belongs to Oncology; Levonorgestrel belongs to Endocrine.
Pourquoi elle survient
Possible induction of CYP3A4 by enasidenib altering levonorgestrel clearance; not fully established.
Conduite à tenir
Use an additional reliable non-hormonal contraceptive method during enasidenib therapy. Do not rely on hormonal contraception alone.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Levonorgestrel
- Amobarbital + Levonorgestrel Majeure
- Apalutamide + Levonorgestrel Majeure
- Belzutifan + Levonorgestrel Majeure
- Bosentan + Levonorgestrel Majeure
- Brigatinib + Levonorgestrel Majeure
- Carbamazepine + Levonorgestrel Majeure
Autres interactions de Enasidenib
Questions fréquentes
Can I take Enasidenib with Levonorgestrel?
MediHelp rates the interaction as moderate. Enasidenib and Levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enasidenib may induce CYP3A4 and alter hormonal contraceptive concentrations, and the labeling advises that its effect on contraceptives is uncertain. Reduced efficacy is possible. Enasidenib also carries embryo-fetal risk, making reliable contraception important.
How serious is the interaction between Enasidenib and Levonorgestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an additional reliable non-hormonal contraceptive method during enasidenib therapy. Do not rely on hormonal contraception alone.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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